Protein kinase B
نویسنده
چکیده
It first came to prominence... in the mid 1990s, when it was shown that PKB is regulated by PI 3-kinase, a lipid kinase that everyone was trying to find effectors for. Is that it? No. The really big excitement came when it transpired that PKB, through the actions of PI 3-kinase, transmits a survival signal that allows cells to suppress apoptosis. Strangely, only two studies have shown a direct genetic link between PKB and apoptosis. These looked at apoptosis in fly development during expression of PKB transgenes. PKB also has a role in glucose metabolism, protein synthesis and more.
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ورودعنوان ژورنال:
- Current Biology
دوره 10 شماره
صفحات -
تاریخ انتشار 2000